L-Glutamine shows potential for AFDaily Supplementation of L-Glutamine in Atrial Fibrillation Patients: The Effect on Heat Shock Proteins and Metabolites.
Directly investigates L-glutamine effects
We examined how L-glutamine supplementation affects patients with atrial fibrillation (AF), particularly focusing on its role in altering levels of heat shock proteins (HSP) and related metabolites. The study engaged 21 patients who were given daily doses of L-glutamine for up to six months to see its effects.
Within just three months, we observed a significant reduction in both HSP27 and HSP70 levels in participants. Specifically, HSP27 levels decreased from 540.39 to 380.69, indicating a promising shift. While HSP70 also showed a decline, its levels remained steady after the initial reduction. Notably, patients starting with high HSP27 levels tended to experience normalization in various metabolites tied to essential metabolic pathways related to carbohydrates, amino acids, and vitamins.
Our findings suggest that L-glutamine can effectively lower certain HSP levels and normalize metabolite concentrations, potentially offering a new avenue for managing AF. This insight opens the door for future research into L-glutamine as a means to enhance heart health and mitigate AF episodes.
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